|
KMID : 0667720070440000462
|
|
Report Natlonal Institute of Health
2007 Volume.44 No. 0 p.462 ~ p.465
|
|
|
Korean Emigrant Study
|
|
Shin Myung-Hee
Kim Mi-Kyeong
Ahn Youn-Jhin
Kim Sung-Soo
Park Man-Seok
|
|
|
Abstract
|
|
|
Purpose : The importance of the migration studies lies on its ability to dissociate the effects of environmental factors from genetic factors. Korean Emigrant Study (KES) is a genomic cohort recruiting Korean emigrants and host country residents to investigate the effect of genetic susceptibility and environmental change on the development of diabetes, hypertension, and metabolic syndrome.
Methods : We selected three sites for our study; Kobe/Osaka(Japan), Yanbian(China), and Jilin(China). The baseline survey was conducted between 2005 and 2007. From each site, equal numbers of Korean emigrants and host-country residents were recruited. We developed a questionnaire to measure life-style characteristic and detailed protocol for the Health examinations and bio-specimen handling. For diet, a new food frequency questionnaire (FFQ) was developed for each site. Dietary validation studies were conducted for each FFQ, collecting four 3-day 24-hour recalls
as gold standards for dietary intake. The inclusion criteria of Korean emigrants were 1) having more than 50% of Korean blood, 2) had been living in the host country for more than 15 years, and 3) being aged 40-70. After signing an informed consent, a participant would get a full health examination, answer the 1-hour long questionnaire interview, and donate the blood for bio-specimen bank. Since 2007, we surveyed the new development of the target diseases through mailed questionnaire.
Results : The total recruitment number was 1,125 for Kobe/Osaka, 1,018 for Yanbian, 999 for Jilin. In comparison between Korean and Japanese, significant differences were noted for height in both sexes, weight, waist, hip, body mass
index(BMI), serum cholesterol, systolic blood pressure, and diastolic blood pressure in women. In China, significant differences in hight, weight, waist, hip, BMI, total cholesterol, and triglyceride between Korean and Han-race were noted. In Japan, total calorie intake was not different between the races, but salt, carotein, and fiber intakes were statistically different. Psychosocial Wellbeing Index Short Form(PWISF) scores were generally higher in Koreans than the host-country residents, especially in the sleep and anxiety area in Japan.
Conclusions : KES recruited over 3,000 members from the baseline survey in Kobe, Yanbian, and Jilin. We will continue to follow-up the cohort members to detect the changes in the environmental factors and the new development of the target diseases. Our Study will be an invaluable source for many studies looking at gene-gene,
gene-environmental interactions among Asians.
|
|
|
KEYWORD
|
|
|
emigrant study, genomic cohort, Korean-Japanese study
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|